Monthly Archives: June 2021

News: SoftBank-backed construction giant Katerra said to be shutting down after raising billions

After burning through more than $2 billion in funding, SoftBank-backed construction startup Katerra has told employees that it will be shutting down operations, according to a report in The Information. Last year, the company claimed it had more than 8,000 employees globally. Menlo Park-based Katerra had already been struggling to find a viable business in

After burning through more than $2 billion in funding, SoftBank-backed construction startup Katerra has told employees that it will be shutting down operations, according to a report in The Information.

Last year, the company claimed it had more than 8,000 employees globally.

Menlo Park-based Katerra had already been struggling to find a viable business in cheaply building apartments properties for real estate developers when it was pushed to the edge of bankruptcy late last year, with the company blaming its latest struggles on climbing labor and material costs associated with the pandemic. The company was given one last chance after receiving a $200 million bailout from SoftBank, which reportedly bought up a majority stake after already having invested billions in the effort.

Katerra’s fall marks the most high-profile failure for SoftBank since the failed 2019 WeWork IPO. The firm has largely been seeing gains among its Vision Fund portfolio in the past year amid a larger tech stock rally, though some of those gains have receded in recent months.

In an interview with Barron’s last month, CEO Masayoshi Son highlighted Katerra as well as SoftBank’s investment in Greensill as “regrets” of his. Katerra’s other backers included Khosla Ventures, DFJ Growth, Greenoaks Capital and Celesta Capital.

TechCrunch has reached out to Katerra for comment.

 

News: Daily Crunch: Wefox CEO says $650M Series C was ‘much more than we wanted to raise initially’

Hello friends and welcome to Daily Crunch, bringing you the most important startup, tech and venture capital news in a single package.

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Hello, and welcome to Daily Crunch for June 1, 2021. We’re back from a long weekend here in the United States, which means that the blog has been humming all day. Today’s tech and startup news had a fun mix of the old going new (7-Eleven adding EV charging points), and new going old (check out this new diaper startup), but mostly we had funding rounds. Lots of them. So let’s get to work! — Alex

The TechCrunch Top 3

  • European tech is hot: EU-based insurtech startup Wefox announced a $650 million round today. The huge round will surely help burnish Europe’s Q2 venture capital results, while also underscoring how the neoinsurance provider boom that we’ve seen in America is hardly a domestic affair. Expect more investment and startup activity in this space during the rest of 2021.
  • Hadoop is not: Cloudera and Hortonworks were once hot startups. They both went public. And then they struggled. So they teamed up in a $5.2 billion merger. And then they struggled. And now their combined entity is being taken off the public markets by a pair of private equity companies for $5.3 billion, a modest premium on their pre-deal value. Thus concludes Hadoop’s startup run.
  • The IPO boom continues: But while The Artist Formerly Known As Hortonworks takes its leave, many companies are looking to join the public markets. Sprinklr, for example. The New York-based customer experience startup is looking to list on the back of modest revenue gains and possibly improving profitability.

Startups and VC

The last 24 hours have brought a steady deluge of startup rounds. We can’t fit them all in the newsletter. But here are some of our favorites all the same:

  • Molecule.one raises $4.6M for computational chemistry: Former TechCrunch Disrupt Battlefield participant Molecule.one wants to “bring theoretical drug molecules to reality,” we reported, creating workflows to help labs figure out how to make exotic molecules from known materials and methods.
  • project44 raises $202M for supply chain APIs: project44 uses APIs to provide “connective tissue” between the myriad players in the supply chain world. The company is now worth $1.2 billion, a rapid-fire doubling of its prior valuation. That’s thanks to money from Goldman Sachs and rapid growth. TechCrunch reports that the company has “crossed $50 million in annual recurring revenue (ARR), which is up 100% year over year.”
  • Redacted raises $60M for proactive cybersecurity: Most cybersecurity software feels defensive. Redacted, fresh out of stealth, wants to flip that narrative and, instead, “proactively [go] after the hackers to recover data loss and disrupt their activities.” There are probably fun legal questions at play here, but it’s a nice mental image at least.
  • Truebill raises $45M for its personal finance app: Early in life Truebill was a neat way to cancel subscriptions. But like all consumer fintech products in 2021, it has become a broad service that offers a host of features and capabilities. Savings? Sure. Credit information? Why not. You get the idea.
  • Belvo raises $43M for fintech APIs: Since Belvo first took part in Y Combinator, we’ve been pretty positive about the company’s chances. Building a sort of Plaid for the Latin American market, it seemed like a pretty darn good bet. And today’s news that the company has put together a fresh $43 million in funding somewhat backs up our early read.

 4 proven approaches to CX strategy that make customers feel loved

People have been working to optimize customer experiences (CX) since we began selling things to each other.

A famous San Francisco bakery has an exhaust fan at street level; each morning, its neighbors awake to the scent of orange-cinnamon morning buns wafting down the block. Similarly, savvy hair stylists know to greet returning customers by asking if they want a repeat or something new.

Online, CX may encompass anything from recommending the right shoes to AI that knows when to send a frustrated traveler an upgrade for a delayed flight.

In light of Qualtrics’ spinout and IPO and Sprinklr’s recent S-1, Rebecca Liu-Doyle, principal at Insight Partners, describes four key attributes shared by “companies that have upped their CX game.”

(Extra Crunch is our membership program, which helps founders and startup teams get ahead. You can sign up here.)

Big Tech Inc.

Big Tech news on the blog was somewhat light today thanks to the pace of startup happenings. But we still found time to discuss how Twitter is making room for more ads on its service. But don’t worry — unless you use its Fleets service, you probably won’t see them.

While Daily Crunch has been positive concerning Twitter’s general product work of late, this is one update that we’d be happy to skip.

Then from Line, news that the messaging app best known for its market share in certain Asian markets is now a bank. Basically. TechCrunch wrote that the well-known tech company “launched a digital banking platform in Indonesia today” that will include “deposit accounts, microcredit products, and remittance and payment services.”

It’s a joke in tech that every messaging app is really a dating service. That’s so old-fashioned. Now every app is simply a service that exists somewhere on the evolutionary continuum of becoming — slowly or quickly — a horizontal fintech offering.

Community

Another IPO, but will it be a successful public offering? Tell us what you think will happen with Sprinklr.

You’ve probably heard about our upcoming field trip to Pittsburgh, which even the mayor is excited about. Have friends building companies in the Steel City? Ask them to sign up to pitch during the event.

And while you’re clicking around, come visit us on Discord.

TC Eventful

You’re invited to tomorrow’s Extra Crunch Live event, where Coda CEO Shishir Mehrotra and Madrona investor S. Somasegar will break down how Coda managed to rise above the noise in the collaborative software space and raise $140 million in funding. You’ll even get your chance to show off your pitching skills during the pitch-off. Grab your seat tomorrow at 11:30 a.m. PDT/2:30 p.m. EDT by registering here!

News: Extra Crunch roundup: Inside Sprinklr’s IPO filing, how digital transformation is reshaping markets

Since we were off yesterday for Memorial Day, today’s roundup is brief, but we’ll have much more to recap on Friday.

Despite a recent history of uneven cash flow and moderate growth, SaaS customer experience management platform Sprinklr has filed to go public.

In today’s edition of The Exchange, Alex Wilhelm pores over the New York-based unicorn’s S-1 to better understand exactly what Sprinklr offers: “Marketing and comms software, with some machine learning built in.”

Despite 19% growth in revenue over the last fiscal year, its deficits increased during the same period. But with more than $250 million in cash available, “Sprinklr is not going public because it needs the money,” says Alex.

Since we were off yesterday for Memorial Day, today’s roundup is brief, but we’ll have much more to recap on Friday. Thanks very much for reading Extra Crunch!

Walter Thompson
Senior Editor, TechCrunch
@yourprotagonist


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Once a buzzword, digital transformation is reshaping markets

Digital transformation concept. Binary code. AI (Artificial Intelligence).

Image Credits: metamorworks / Getty Images

The changes brought by a global shift to remote work and schooling are myriad, but in the business realm, they have yielded a change in corporate behavior and consumer expectations — changes that showed up in a bushel of earnings reports last week.

Startups have told us for several quarters that their markets are picking up momentum as customers shake up buying behavior with a distinct advantage for companies helping users move into the digital realm.

Public company results are now confirming the startups’ perspective. The accelerating digital transformation is real, and we have the data to prove it.

3 views on the future of meetings

In a recent episode of TechCrunch Equity, hosts Danny Crichton, Natasha Mascarenhas and Alex Wilhelm connected the dots between multiple funding rounds to sketch out three perspectives on the future of workplace meetings.

Each agreed that the traditional meeting is broken, so we gathered their perspectives about where the industry is heading and which aspects are ripe for disruption:

  • Alex Wilhelm: Faster information throughput, please.
  • Natasha Mascarenhas: Meetings should be ongoing, not in calendar invites.
  • Danny Crichton: Redesign meetings for flow.

News: Twitter’s acquisition strategy: eat the public conversation

Twitter is trying to revitalize itself by adding more contexts for discourse to its repertoire. The result, if everything goes right, will be an influence superapp that hasn’t existed before.

Evan J. Zimmerman
Contributor

Evan J. Zimmerman is the founder and CEO of Drift, a genomics software company, and chairman of Jovono, a venture capital firm.

The last few months have been interesting for Twitter.

After years of no innovation at all, Twitter is making big product changes. It has acquired Breaker and Revue, and presumably has more M&A coming. It’s coming out with Spaces. The only thing it clearly isn’t working on is an edit button.

The core idea is that Twitter is doubling down on multichannel engagement for creators so that they never have to leave for anywhere else.

Strategically, though, what is a microblogging service doing buying a social podcasting company and a newsletter tool while also building a live broadcasting sub-app? Is there even a strategy at all?

I humbly propose this: There is a strategy. Twitter is trying to revitalize itself by adding more contexts for discourse to its repertoire. The result, if everything goes right, will be an influence superapp that hasn’t existed anywhere before. The alternative is nothing less than the destruction of Twitter into a link-forwarding service.

Let’s talk about how Twitter is trying to eat the public conversation.

Why now?

Twitter’s problem is pretty simple. It’s this.

Twitter revenue quarterly growth 2013-21

Twitter revenue quarterly growth 2013-21. Image Credits: Macrotrends

Another way of putting it is: Twitter is not generating as much money from ads as it used to. Ad revenue has failed to grow because Twitter is generally considered to have a poorly performing product for marketers. As a result, its stock price has been flat for years.

The irony, though, is that Twitter became more socially important during this period of financial stagnation to the point that the president of the United States nearly launched several wars on the platform!

The core reason is that since becoming a public company, Twitter has been considered by most to be one of the most boring tech companies productwise. Yes, people joke about the lack of an edit button, but the platform really has been slow to innovate in any real way.

Twitter was one of the most dynamic companies around, going from the fail whale company to being the company that invented the hashtag and acquiring some of the hottest companies, from Periscope to Vine.

But it all failed. Twitter rarely used acquisitions successfully. It stopped putting out new features and barely even managed simple improvements. Despite describing itself as “what’s happening now,” it missed every boat. Until this year.

What changed?

  1. Twitter started to face its first real competition in years due to the social media renaissance. Twitter’s strength has always come from being where the news happens. Podcasts, Clubhouse, newsletters and other new channels are true competitive threats.

News: Ditto raises $1.5 million to help teams collaborate on copy

Even as remote software uptake has boomed during the pandemic, certain workflows have gotten prioritized for specialized toolsets while other team members have been left piecemealing their productivity. Employees designing the copy that directs users and encapsulates company messaging have been particularly forgotten at times, say the founders of Ditto, a young startup building software

Even as remote software uptake has boomed during the pandemic, certain workflows have gotten prioritized for specialized toolsets while other team members have been left piecemealing their productivity. Employees designing the copy that directs users and encapsulates company messaging have been particularly forgotten at times, say the founders of Ditto, a young startup building software focused on finding a “single source of truth” for copy.

The startup was in Y Combinator’s winter 2020 batch (we selected it as one of our favorites from the class), now Ditto’s founders tell TechCrunch the team has raised a $1.5 million seed round from investors including Greycroft, Y Combinator, Soma Capital, Decent Capital, Twenty Two VC, Holly Liu and Scott Tong, among others.

While copy workflows are often very messy when it comes to design and implementation, even the most-organized teams are often left scouring through meandering email threads, screenshot dumps and slack DMs with disparate teams. The founders behind Ditto hope that their software can give copy teams the home they deserve to keep everything organized and synced across projects and applications, ensuring that language is actually finalized and ready to ship when the time comes.

The company’s founders Jessica Ouyang and Jolena Ma were Stanford roommates who saw a lingering opportunity to build a toolset that prioritized copy as its own vertical.

“It’s so easy to couple text with where it lives, like you may think of it as part of the design so a lot of writers have to manage it inside toolsets for design or you may already think of it as part of development so writers end up having to go into the codebase and figure out how to code or manage JSON even though they’re content designers,” Ouyang tells TechCrunch.

Out of the gate, Ditto has been built for Figma, meaning users can easily export text blocks from designs in the app and rework them inside the Ditto web app, pushing updates without having to dig through the designs themselves. The founders say they are currently working on building out integrations for Sketch and Adobe XD as well. Inside the Ditto web app users can access change logs and update the status of particular pieces of text inside a project so that approvals are always certain.

“We find there’s a lot more opportunity to integrate into all of the places where copy is being worked on,” Ma tells us. “We have a lot more we’re hoping to do with our developer integrations and just integrating to all of those places where copy lives, places like A/B testing, internationalization, localization and other workflows.”

Copy development has plenty of stakeholders and the team is looking to experiment with pricing tiers that address that. For now they split up users into editors and commenters paying $15 and $10 monthly (priced annually) respectively on the startup’s Teams plan. Ditto has a free tier for teams of two as well and pricing designed for larger enterprise clients.

 

News: Unit tests an easier way for workers to organize

Work looks wildly different today than it did a year ago. In tech, every bit of the workplace has been tweaked to fit our new remote world. From scaling accountability and onboarding remotely to figuring out what old perks can be made socially distant — myriad decisions have been made at the hands of the

Work looks wildly different today than it did a year ago. In tech, every bit of the workplace has been tweaked to fit our new remote world. From scaling accountability and onboarding remotely to figuring out what old perks can be made socially distant — myriad decisions have been made at the hands of the employers.

An early-stage startup thinks it’s time to give some of that decision-making power back to employees, too. So Unit, a New York-based company, is tackling perhaps the most elusive and controversial topic in mainstream tech today: labor unions.

Numerous studies show that union members earn significantly higher wages and get better benefits than non-union workers. At the same time, many companies are anti-union because it impacts the bottom line, or puts more autonomy into their workers’ hands and limits control.

Unit wants to make it easier for employees to virtually organize, and manage, labor unions to protect them from their employers. Unit itself is not a labor union, but instead helps worker-organizers set up, affiliate and manage a union with a mix of software and human resources.

Janitorial entrepreneurship

Unit founder and CEO James White watched Occupy Wall Street unfold in real time while he was a graduate student. He helped out a cohort of janitorial workers from MIT and Harvard that were organizing with the SEIU, or Service Employees International Union, a union of about 2 million people across the services industry.

“By day I would be working in the bio-instrumentation lab at MIT on medical injection devices, and by nights and weekends we were organizing students to support these janitors in their bid for better pay and working conditions,” he said. “[Volunteer organizing] felt very manual and inefficient, but they won some things. It took a couple of years, but they won.”

White spent most of the next decade picking the day job, and worked on a company in the medical device space. But after getting business and sales chops, he left to start his own business. He kept thinking about labor unions.

“Tech-enabled organizing kept coming back to the forefront [of my ideas], and being both the most exciting to me personally, but also I think the most impactful in the ways I wanted to see the world change in terms of income inequality and individual empowerment,” he said.

A turnkey solution for unions

Unit offers a suite of services to fix the process of unionizing, which starts with education. The startup has a step-by-step process of how to virtually unionize a workplace that it offers for free public use on its website.

After a worker-organizer decides that they want to unionize, Unit helps them begin the process. Employees can come to the website, run through an eligibility survey, and begin to start inviting fellow co-workers to the organizing platform. Interested employees will fill out paperwork and a small cohort will begin to form within an organization.

In the background, Unit begins handling the legal automation process needed before a team approaches a national union, such as the national Labor Relations Board, or local union with their pitch. The startup works with a Boston law firm that files the petitions on behalf of employees.

“So far, the biggest feedback we’ve gotten from our organizing application is that ‘I chose you guys over calling a labor organizer at a national union or over contacting volunteers to come and help us because it seemed like the fastest way to get started’,” White said.

After (and if) a union is approved, Unit takes on the role of a labor advisory service. The startup uses a combination of digital and human services to create a “turnkey solution” for union management.

The startup will help conduct voting and polling, provide consensus tools and oversee the charter draft and review process, otherwise known as the governance of a union, on behalf of workers. It will also help with negotiation, such as bargaining surveys, contract drafting and review, compensation and strategic analysis. Beyond that, Unit focuses on ongoing organizing such as new member education and strike planning, as well as contract maintenance. Another company in the space, UnionWare, helps with membership management, while Unit is aiming for the full suite.

“We plan to try to take the time commitment down by quite a bit by automating a bunch of it,” he said. “So that people can vote over software, they can get updates over software, nominate new officers or run for office within these small unions over software.” A Shopify for union organizers, of sorts.

Similar to how an employee only pays fees once a union is approved, Unit only charges a fee after the formation process is complete. The typical cost of national union dues is 1.5% of wages, the company said, meaning that an employee who makes $40,000 a year would pay about $50 a month. Unit charges 0.8% of those monthly earnings.

The “no strings attached” business model means that Unit could lose 90% of their customers once the union is approved, White said. The startup is in the process of forging partnerships with large national unions so that it gets paid whenever a Unit-approved union that comes through one of its networks gets affiliated — with the pitch that it saves unions time and resources through its software.

Customers include software developers, digital media companies, fast food franchises and mental health companies, with a specific focus on helping smaller companies unionize.

‘It’s not a technical problem we have to solve’

Arianna Jimenez, who was a labor organizer for 20 years at SEIU, expressed caution around oversimplifying the unionizing process, which she thinks could give a false sense of hope to workers. In her experience, the negotiation process is the most contentious part of unionizing, taking anywhere from six months to 10 years.

“Once you have signed the cards and you are technically a union in the eyes of the law, that doesn’t in and of itself bring a change in the material conditions of the workers’ lives,” she said. “What brings the change is that the workers are engaging in a legal process that is protected by law with the employer officially to change the contract — such as increased benefits, healthcare and pension.”

While Unit and labor organizers across the country help with the negotiation process, employer-led oppression and fear tactics can often force employees to worry about their livelihoods, and thus vote against forming a union. For example, earlier this year Amazon conducted an anti-union campaign to pressure employees to vote against organizing efforts. The corporation defeated the union attempts, a setback for the biggest unionization push in Amazon’s 27-year history.

Jimenez doesn’t think that unionizing could ever have a fully turnkey solution because “the transformation fundamentally for workers between having a union and not having a union is not a legal threshold. It is really a more intangible transformation from a group of people who feel disempowered and disenfranchised to not.”

Jimenez says hitting scale for Unit would mean rewriting U.S. labor laws.

“It’s not a technical problem we have to solve, it’s a problem of values,” she said.

When venture is the elephant in the room

To scale, Unit will have to lean on VC, per White. In July 2020, Unit closed $1.4 million in financing, from investors such as Bloomberg Beta, Draper Associates, Schlaf Angel Fund, Haystack, E14 and Gutter Capital.

And this is where the heart of the tension with Unit is, per White: It needs to raise venture capital to hit scale, but getting in bed with that very asset class can feel counterintuitive.

For example, what if Unit helps employees within portfolio companies of existing investors start unions? Is there a conflict of interest, or can Unit be swayed to not prioritize those clients in order to keep its cap table happy?

Last year, California voters passed Proposition 22, essentially supporting Uber, Lyft, DoorDash, Instacart and Postmates that gig workers should not be entitled to the same labor right as employees, staying as independent contractors. The move was a blow to the efforts of worker-organizers around the world, and a reminder that venture-backed companies can be incentivized to act against broader access to benefits and worker protections.

While White says that venture was the best option for speed and scale, he did admit to worrying about some of these concerns, specifically about the influence that investors might try to have in later rounds if the founding team is unable to keep the majority of the company. He hopes that Unit can operate off of little venture capital for as long as possible to delay or altogether avoid those interests.

Siri Srinivas, an investor at Draper, thinks of Unit as a service that is building a better tool for a process that is regulated and complex. In other words, stripping out the politics, it’s a SaaS tool that makes sense.

“Frankly as VCs, we invest in technologies that people want. We as a team make a hard call on not engaging with certain products (e.g. tobacco) which we think are net negative for the world but don’t see this as much different from investing in other companies building software products in regulated industries,” she said. “Unit allows for a form of worker equity and can unlock a lot of value for its users and in that our incentives are completely aligned.”

For now, White is hoping that general interest in rebuilding workplaces keeps Unit busy and revenue-generating.

“We never could have predicted COVID having the impact that it did and really igniting even more conversations around labor and safety,” he said. “I do think, when we face these problems on a national level, sometimes they hit everybody at once and people think about the same things at the same time.”

News: 4 proven approaches to CX strategy that make customers feel loved

CX can’t be thought of as a special project or the responsibility of a single function, such as user research. It needs to be a way of life.

Rebecca Liu-Doyle
Contributor

Rebecca Liu-Doyle is principal at Insight Partners, a global private equity and venture capital firm. Her focus areas include high-growth software, marketplaces, and consumer internet.

Customers have been “experiencing” business since the ancient Romans browsed the Forum for produce, pottery and leather goods. But digitization has radically recalibrated the buyer-seller dynamic, fueling the rise of one of the most talked-about industry acronyms: CX (customer experience).

Part paradigm, part category and part multibillion-dollar market, CX is a broad term used across a myriad of contexts. But great CX boils down to delighting every customer on an emotional level, anytime and anywhere a business interaction takes place.

Great CX boils down to delighting every customer on an emotional level, anytime and anywhere a business interaction takes place.

Optimizing CX requires a sophisticated tool stack. Customer behavior should be tracked, their needs must be understood, and opportunities to engage proactively must be identified. Wall Street, for one, is taking note: Qualtrics, the creator of “XM” (experience management) as a category, was spun-out from SAP and IPO’d in January, and Sprinklr, a social media listening solution that has expanded into a “Digital CXM” platform, recently filed to go public.

Thinking critically about customer experience is hardly a new concept, but a few factors are spurring an inflection point in investment by enterprises and VCs.

Firstly, brands are now expected to create a consistent, cohesive experience across multiple channels, both online and offline, with an ever-increasing focus on the former. Customer experience and the digital customer experience are rapidly becoming synonymous.

The sheer volume of customer data has also reached new heights. As a McKinsey report put it, “Today, companies can regularly, lawfully, and seamlessly collect smartphone and interaction data from across their customer, financial, and operations systems, yielding deep insights about their customers … These companies can better understand their interactions with customers and even preempt problems in customer journeys. Their customers are reaping benefits: Think quick compensation for a flight delay, or outreach from an insurance company when a patient is having trouble resolving a problem.”

Moreover, the app economy continues to raise the bar on user experience, and end users have less patience than ever before. Each time Netflix displays just the right movie, Instagram recommends just the right shoes, or TikTok plays just the right dog video, people are being trained to demand just a bit more magic.

News: Venrock’s Camille Samuels is joining us to judge Startup Battlefield at Disrupt 2021

The team at TechCrunch is preparing for another epic Startup Battlefield competition this year at Disrupt 2021 on September 21-23 and we’re assembling a superstar team of judges that will choose the winner who gets to take home $100K and the Disrupt Cup. We’re thrilled to have Venrock’s Camille Samuels join us as one of

The team at TechCrunch is preparing for another epic Startup Battlefield competition this year at Disrupt 2021 on September 21-23 and we’re assembling a superstar team of judges that will choose the winner who gets to take home $100K and the Disrupt Cup. We’re thrilled to have Venrock’s Camille Samuels join us as one of our esteemed Battlefield judges at our second virtual Startup Battlefield.

Samuels is a partner at Venrock, building out the team’s investments in the healthcare world, focusing specifically on plays in biotech, medical devices and consumer health. Some recent bets include Unity Biotechnology, Iris Medicine and Biolux. Samuels joined Venrock in 2014 after 12 years at healthcare-centric firm Versant Ventures. Before the start of her 20+ year career in venture, Samuels worked in business development at drug discovery company Tularik and had stints in corporate development at Genzyme and Millennium Predictive Medicine.

When we spoke with Samuels early last year she talked about her interests in technology that could keep people healthier for longer. “In general, the big idea of improving health span is what really interests me. I want us to extend out the years that we can be healthy and happy versus on medication and decrepit,” she told us.

It’s been a big year for Venrock, which recently closed its ninth fund with $450 million; the firm’s latest exits include last year’s IPOs of Cloudflare and 10x Genomics.

Disrupt 2021 runs September 21-23 and will be 100% virtual this year. Get your pass to attend with the rest of the TechCrunch community for less than $100 if you secure your seat before next month.

 

News: Molecule.one grows its drug synthesis AI platform with a $4.6M seed round

Polish computational chemistry outfit Molecule.one has raised $4.6M to expand its quest to bring theoretical drug molecules to reality. Its machine learning systems predict the best ways to synthesize potentially valuable molecules, a crucial part of creating new drugs and treatments. Molecule.one went on stage at Disrupt SF 2019’s Startup Battlefield, where they explained the

Polish computational chemistry outfit Molecule.one has raised $4.6M to expand its quest to bring theoretical drug molecules to reality. Its machine learning systems predict the best ways to synthesize potentially valuable molecules, a crucial part of creating new drugs and treatments.

Molecule.one went on stage at Disrupt SF 2019’s Startup Battlefield, where they explained the difficulty faced by the drug discovery industry, basically that they come up with lots of theoretical treatments but can’t actually make the molecules.

The company’s system enters play when you have some exotic new compound you want to make in order to test it in real life, but don’t know how to make it. After all, these molecules are brand new to science — no one has created them before, so why should anyone know? Molecule.one creates a workflow starting with ordinary off-the-shelf chemicals and provides step by step instructions using known methods of how to go from A to B… and to C, D, and so on (it’s rarely simple).

The company leverages machine learning and a large body of knowledge about chemical reactions to create these processes, though as CSO Stanisław Jastrzębski explained, they do it backwards.

“Synthesis planning can be characterized as a game,” he said. “In each move of this game, instead of moving a piece on a board, we break a chemical bond between a pair of atoms. The goal of the game is to break down a target molecule to molecules that can then be bought on the market and used to synthesize the target. We use algorithms similar to the ones used by DeepMind to master Go or chess to find the synthesis pathway.”

Co-founders Piotr Byrski and Paweł Włodarczyk-Pruszyński note that predicting organic reactions is no cakewalk, and that they have dedicated a great deal of resources towards making their system efficient and verifiable. The theoretical pathways they produce seem plausible but still need to be tested, something they do regularly internally so companies see that Molecule.one just selling good ideas but workable ones.

Since their debut at Disrupt, the company has acquired a number of customers with annual contracts, Byrski said, and rolled out lots of features on the platform. Włodarczyk-Pruszyński said that their efficiency has increased as well.

Molecule.one founders Piotr Byrski and Paweł Włodarczyk-Pruszyński in a lab.

Image Credits: Molecule.one

“Our system has matured and we have extended our platform to support planning synthesis for thousands of molecules per hour,” he said. “This feature is incredibly useful when combined with AI systems for drug discovery that generate huge numbers of candidate drug molecules. All these improvements helped us gain trust in the industry and initiate collaborations with relevant parties.”

Certainly the problem becomes one of scaling as your customers start asking about pathways for hundreds of thousands of possible therapeutic molecules rather than a handful. For them, if they are to bear the manufacturing cost, it’s worth the outlay at the start to see if one of the compounds they’re looking at is considerably easier to make than another with a similar effect. Without simulating the entire process that’s difficult to say for sure, so they can just send the list to Molecule.one and get the report back a few days later.

Screenshot of the Molecule.one interface, showing chemical structures.

Image Credits: Molecule.one

The team can’t share any of their customers’ successes (though presumably there have been some) because of course all this work is highly confidential. But they did say that like many companies in biotech they are doing what they can to support COVID-related therapies.

“We made part of our platform free to eligible researchers working on COVID drug discovery. This has resulted in a lasting collaboration with the LambdaZero project at MILA, which is advised by Prof. Yoshua Bengio,” said Byrski.

This also offered the opportunity to test their new scaling methods, since for such a project many candidate molecules must be evaluated, not just for efficacy but the capability of being manufactured easily.

“We are incredibly excited about this area in general because it enables traversing novel regions of the chemical space, which offers enormous promise in terms of looking for drugs that have not yet been synthesized,” Byrski said.

The funding round was led by Atmos Ventures, with a long list of participating investors: AME Cloud Ventures, Cherubic Ventures, Firlej Kastory, Inventures, Luminous Ventures, Sunfish Partners, and individuals including Bayer executive Sebastian Guth.

The company plans to use the money to expand the team and continue expanding generally; it also has a plan to open new offices in the U.S. and Western Europe (they’re based in Poland).

News: Former head of Alphabet’s Loon joins Starship Technologies as new CEO

Autonomous robotics company Starship Technologies has a new CEO. The company on Tuesday said Alastair Westgarth, the former CEO of Alphabet’s Loon, would be leading the company as it looks to expand its robotics delivery service. Westgarth previously headed Loon, Alphabet’s experiment to deliver broadband via high-altitude balloons, from 2017. The project shut down for

Autonomous robotics company Starship Technologies has a new CEO. The company on Tuesday said Alastair Westgarth, the former CEO of Alphabet’s Loon, would be leading the company as it looks to expand its robotics delivery service.

Westgarth previously headed Loon, Alphabet’s experiment to deliver broadband via high-altitude balloons, from 2017. The project shut down for good at the beginning of this year. The company said in a farewell blog post that “the road to commercial viability has proven much longer and riskier than hoped.” Prior to working at Loon, Westgarth headed the wireless antennae company Quintel Solutions, was a vice president at telecommunications company Nortel and director of engineering at Bell Mobility.

He will be joining Starship Technologies at a time of rapid expansion. At the beginning of 2020, Starship only had a couple hundred autonomous bots operating in a few neighborhoods and college campuses. Last month the company said the number of deliveries since the start of the pandemic quadrupled, hitting a milestone 1.5 million commercial deliveries globally.

“Autonomous delivery is changing logistics as we know it, impacting billions of people around the world,” Westgarth said in a statement Tuesday. “The team at Starship has been developing and perfecting the technology and its operations for years, since creating the robot delivery category in 2014 […] I’m excited about this opportunity and looking forward to helping the company scale both on campuses and in neighborhoods, giving millions more people access to this market-leading, convenient, safe and environmentally friendly delivery service.”

Starship’s previous CEO Lex Bayer quietly departed in December 2020, after nearly three years at the helm. Its co-founder Ahti Heinla, who acted as interim CEO, will now become Starship’s CTO.

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