News: People with this certain gene version less likely to develop severe COVID-19

The new results show that people with a specific version of a gene are less likely to develop severe COVID-19. Earlier research had identified a specific group of genes, called the OAS1/2/3 gene cluster, as being involved in the risk for severe COVID-19. One version of a gene in that cluster –passed down from Neanderthals, appeared to protect against serious disease, reducing  risk by about 23%. Previous research was mostly done on people of European ancestory. Researchers are now seeing the same association of this genetic variant with less severe COVID-19 in people of African ancestory, according to a report published in Nature Genetics. “The fact that people of African descent had the same protection allowed us to identify the only variant in  DNA that actually protects against COVID19 infection. co-author dr. Jennifer Huffman  said in a statement. OAS genes are involved in a cascade of effects that help cells fight viruses, the researchers said. Understanding these genes and their impact on COVID19 risks could aid in the development of future drugs, they added.Fewer Delta breakthroughs with Moderna vs Pfizer/BioNTechWhen the delta variant  coronavirus was widespread in the United States, recipients of two doses of Moderna’s mRNA vaccine (MRNA.O) were less likely to have breakthrough infection  and  were slightly less likely to be hospitalized  than recipients of two doses of  mRNA vaccine from Pfizer and BioNTech, found a large study. The researchers analyzed the medical records of more than 637,000 vaccine recipients who had not previously been infected with the virus and had not received a booster shot. As reported in JAMA on Thursday, advanced infections increased steadily each month from July through November 2021, with higher rates in the Pfizer/BioNTech group. In November, there were 2.8 cases per thousand people vaccinated with the Pfizer/BioNTech injections compared to 1.6 cases per thousand recipients of the Moderna vaccines.

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The new results show that people with a specific version of a gene are less likely to develop severe COVID-19. Earlier research had identified a specific group of genes, called the OAS1/2/3 gene cluster, as being involved in the risk for severe COVID-19. 

One version of a gene in that cluster –passed down from Neanderthals, appeared to protect against serious disease, reducing  risk by about 23%. Previous research was mostly done on people of European ancestory. Researchers are now seeing the same association of this genetic variant with less severe COVID-19 in people of African ancestory, according to a report published in Nature Genetics.

 “The fact that people of African descent had the same protection allowed us to identify the only variant in  DNA that actually protects against COVID19 infection. co-author dr. Jennifer Huffman  said in a statement.

 OAS genes are involved in a cascade of effects that help cells fight viruses, the researchers said. Understanding these genes and their impact on COVID19 risks could aid in the development of future drugs, they added.

Fewer Delta breakthroughs with Moderna vs Pfizer/BioNTech

When the delta variant  coronavirus was widespread in the United States, recipients of two doses of Moderna’s mRNA vaccine (MRNA.O) were less likely to have breakthrough infection  and  were slightly less likely to be hospitalized  than recipients of two doses of  mRNA vaccine from Pfizer and BioNTech, found a large study. 

The researchers analyzed the medical records of more than 637,000 vaccine recipients who had not previously been infected with the virus and had not received a booster shot.

 As reported in JAMA on Thursday, advanced infections increased steadily each month from July through November 2021, with higher rates in the Pfizer/BioNTech group. 

In November, there were 2.8 cases per thousand people vaccinated with the Pfizer/BioNTech injections compared to 1.6 cases per thousand recipients of the Moderna vaccines.

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